Anti Aging

Neurodegenerative Diseases
Written by Administrator
Wednesday, 18 March 2015 05:02

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359723/

 

Today the most widespread neurological problems are considered neurodegenerative diseases of aging such as Alzheimer's and Parkinson's that rob people from their golden years causing early debilitation and dependency on special care. Despite all advances in neuroscience in recent decades, age-associated cognitive decline resulting from neurodegenerative processes in the brain remains a challenge for researchers and clinicians due to the highly complex nature of its pathogenesis.

Currently, the key processes leading to neurodegeneration are thought to be oxidative stress, disruption of transitional metal homeostasis, and neuroinflammation [12].

There is also growing evidence that neurodegenerative diseases such as Alzheimer's and Parkinson's may be caused by detrimental environmental and dietary factors that alter gene expression by means of DNA methylation and histone modification [3].

Since the importance of oxidative stress in the development of age-related neurodegeneration is well established, a number of antioxidant compounds are considered promising in prevention of neurodegenerative disorders, including vitamin E, melatonin, green tea polyphenols, resveratrol, and others [4]. However, so far the clinical studies produce mixed results with many promising approaches such as vitamin E therapy failing to slow down the progression of age-related neurodegenerative conditions [5]. There are also studies investigating an effect of metal chelators and dietary approaches aimed at reducing intake of iron and copper [6]. Finally, researchers are investigating diverse compounds capable of favorably altering gene expression (epigenetic modifiers), reversing effects of environmental perturbagens [7].

The human copper-binding tripeptide glycyl-L-histidyl-L-lysine (GHK) is a compound with a long history of safe use in wound healing and antiaging skin care. Since its discovery in 1973, almost four decades of extensive research have established its diverse beneficial actions in many organs and tissues including nervous tissue, skin, intestine, bone, and blood vessels. The molecule has a high affinity for Cu (II) and forms the chelate GHK-Cu. The GHK copper complex (or GHK-Cu) has been proven to exhibit antioxidant, anti-inflammatory, regenerative, and wound healing actions [8]. Recent studies demonstrated that the GHK tripeptide up- and downregulates a large number of human genes, which may contribute to the pleiotropic health promoting effects of its copper complex [9]. We propose that the GHK-Cu complex may act therapeutically against age-associated neurodegeneration and cognitive decline.

 

Read More Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359723/

 

"Controlled studies on aged skin demonstrated that it tightens skin, improves elasticity and firmness, reduces fine lines, wrinkles, photodamage and hyperpigmentation." Source: http://www.ncbi.nlm.nih.gov/pubmed/18644225

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